Cell Therapy for Knee Osteoarthritis: Mesenchymal Stromal Cells
نویسندگان
چکیده
منابع مشابه
Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial.
UNLABELLED : Osteoarthritis (OA) is the most widespread musculoskeletal disorder in adults. It leads to cartilage damage associated with subchondral bone changes and synovial inflammation, causing pain and disability. The present study aimed at evaluating the safety of a dose-escalation protocol of intra-articular injected adipose-derived stromal cells (ASCs) in patients with knee OA, as well a...
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متن کاملMesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients.
BACKGROUND Osteoarthritis (OA) is a cartilage degenerative process, involving the immune system, producing local inflammatory reactions, with production of pro-inflammatory cytokines and metalloproteinases. No treatment is still available to improve or reverse the process. Stem cell therapy opened new horizons for treatment of many incurable diseases. Mesenchymal stem cells (MSCs) due to their ...
متن کاملInfrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis.
PURPOSE The aim of the study was to determine if isolated mesenchymal stem cells (MSCs) derived from the infrapatellar fat pad could effectively improve clinical results when percutaneously injected into arthritic knees. LEVEL OF EVIDENCE Therapeutic case-control study; Level III. METHODS Twenty five stem cell injections combined with arthroscopic debridement were administered to patients w...
متن کاملMesenchymal stem cell injections improve symptoms of knee osteoarthritis.
PURPOSE The purpose of this study was to evaluate the clinical and imaging results of patients who received intra-articular injections of autologous mesenchymal stem cells for the treatment of knee osteoarthritis. METHODS The study group comprised 18 patients (6 men and 12 women), among whom the mean age was 54.6 years (range, 41 to 69 years). In each patient the adipose synovium was harveste...
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ژورنال
عنوان ژورنال: Gerontology
سال: 2019
ISSN: 0304-324X,1423-0003
DOI: 10.1159/000496605